食管鳞状细胞癌中的环状 RNA:目前我们已知多少?

Circular RNAs in esophageal squamous cell carcinoma: What do we know so far?

期刊: iScience
PMID: 42495543
原文: PubMed ↗
发布日期: 2026-07-24

作者

Mingxin Yang — Department of Thoracic Surgery, The First Hospital of China Medical University, No. 155, North Nanjing Street, Shenyang, Liaoning 110001, China.
Jun Ye — Department of Thoracic Surgery, The First Hospital of China Medical University, No. 155, North Nanjing Street, Shenyang, Liaoning 110001, China.
Jiahao Xiong — Department of Thoracic Surgery, The First Hospital of China Medical University, No. 155, North Nanjing Street, Shenyang, Liaoning 110001, China.
Yuhua Chen — Department of Thoracic Surgery, The First Hospital of China Medical University, No. 155, North Nanjing Street, Shenyang, Liaoning 110001, China.
Yanlei Zhao — Department of Thoracic Surgery, The First Hospital of China Medical University, No. 155, North Nanjing Street, Shenyang, Liaoning 110001, China.
Zhitong Wang — Department of Thoracic Surgery, The First Hospital of China Medical University, No. 155, North Nanjing Street, Shenyang, Liaoning 110001, China.
Shun Xu — Department of Thoracic Surgery, The First Hospital of China Medical University, No. 155, North Nanjing Street, Shenyang, Liaoning 110001, China.
Jiajun Wang — Department of Thoracic Surgery, The First Hospital of China Medical University, No. 155, North Nanjing Street, Shenyang, Liaoning 110001, China.

作者单位

Department of Thoracic Surgery, The First Hospital of China Medical University, No. 155, North Nanjing Street, Shenyang, Liaoning 110001, China.

摘要

中文

食管鳞状细胞癌 (ESCC) 是一种高度致命的恶性肿瘤,早期诊断手段有限,有效治疗靶点匮乏。环状 RNA (circRNAs) 是一类稳定的非编码 RNA,已成为 ESCC 肿瘤发生过程中的关键调控因子,在 ESCC 诊断和治疗中展现出巨大的应用潜力。本综述全面概述了 circRNAs 在 ESCC 中的研究进展与前景。我们首先概括 circRNAs 的生物发生机制,并归纳其在 ESCC 中的表达与生物学功能。其中,我们特别强调 circRNAs 通过与蛋白质相互作用调控 ESCC 的机制,以及 circRNAs 在调控肿瘤微环境中的作用。此外,本文还系统总结了现有 circRNAs 研究数据库,以及利用高通量技术研究失调 circRNA 表达的方法学。我们还讨论了新兴技术的转化潜力,包括先进的 circRNA 检测工具、靶向递送系统及基于 circRNA 的疫苗,这些有望为 ESCC 的诊治开辟新途径。circRNAs 是 ESCC 肿瘤进展的核心调控因子,兼具生物标志物与治疗靶点的双重潜力。基于 circRNA 治疗策略的最新进展虽已展现令人鼓舞的结果,但其在临床实践中的转化仍受限于样本量小、缺乏多中心验证以及检测方法不统一等问题。未来研究应继续开展机制验证、多组学整合和前瞻性临床试验,以推动其向 ESCC 治疗策略的真正转化。

English

Esophageal squamous cell carcinoma (ESCC) is a highly lethal malignancy, with limited early diagnostic tools and effective therapeutic targets. Circular RNAs (circRNAs) are a class of stable non-coding RNAs that have emerged as crucial regulators in the process of ESCC tumorigenesis, highlighting their great application potential in ESCC diagnosis and treatment. This review provides a comprehensive overview of current advances and prospects of circRNAs in ESCC. We provide an overview of the biogenesis mechanism of circRNAs and summarize their expression and biological functions in ESCC. Among them, we specifically emphasize the mechanism by which circRNAs regulate ESCC through interaction with proteins and the role of circRNAs in regulating the tumor microenvironment. The review also systematically summarizes the existing circRNA research databases and the use of high-throughput techniques to study dysregulated circRNA expressions. In addition, we discuss the translational potential of emerging technologies, including advanced circRNA detection tools, targeted delivery systems, and circRNA-based vaccines, which are expected to open up new avenues for ESCC diagnosis and treatment. circRNAs are central regulators of ESCC tumor progression, and they have the dual potential as biomarkers and therapeutic targets. The latest developments in emerging technologies for circRNA-based treatment have shown encouraging results, but the transformation of circRNA-based strategies into clinical practice is still limited by small sample sizes, lack of multicenter verification, and inconsistent detection methods. Future research should continue to carry out mechanism verification, multi-omics integration, and prospective clinical trials to promote its transformation into ESCC therapies.

分类与指标

研究类型: 综述Meta
病种: 食管癌
JCR 分区: Q1
影响因子: 4.5
新锐分区: 3区