PER1相关炎症信号通路介导夜班暴露对煤矿工人肺功能降低的影响

PER1-related inflammatory signaling links night shift exposure to lower lung function in coal miners.

期刊: iScience
PMID: 42541301
原文: PubMed ↗
发布日期: 2026-08-02

作者

Zikai Liu — Department of Occupational Health and Environment Health, School of Public Health, Anhui Medical University, Hefei 230032, Anhui, China.
Haihong Pan — Department of Occupational Health and Environment Health, School of Public Health, Anhui Medical University, Hefei 230032, Anhui, China.
Fengtao Cui — Huaibei Occupational Disease Prevention and Control Hospital of Huaibei Coal Mining Group, Huaibei 235000, China.
Qingqing Yang — Department of Occupational Health and Environment Health, School of Public Health, Anhui Medical University, Hefei 230032, Anhui, China.
Zhen Yu — Department of Occupational Health and Environment Health, School of Public Health, Anhui Medical University, Hefei 230032, Anhui, China.
Jiale Chen — Department of Occupational Health and Environment Health, School of Public Health, Anhui Medical University, Hefei 230032, Anhui, China.
Xuan Chen — Department of Occupational Health and Environment Health, School of Public Health, Anhui Medical University, Hefei 230032, Anhui, China.
Yan Lv — Department of Occupational Health and Environment Health, School of Public Health, Anhui Medical University, Hefei 230032, Anhui, China.
Qing Wu — Department of Occupational Health and Environment Health, School of Public Health, Anhui Medical University, Hefei 230032, Anhui, China.
Qi Zhong — Department of Occupational Health and Environment Health, School of Public Health, Anhui Medical University, Hefei 230032, Anhui, China.
Xinping Ding — Huaibei Occupational Disease Prevention and Control Hospital of Huaibei Coal Mining Group, Huaibei 235000, China.
Wei Gao — Huaibei Occupational Disease Prevention and Control Hospital of Huaibei Coal Mining Group, Huaibei 235000, China.
Weihong Chen — Huazhong University of Science and Technology, Tongji Medical College, School of Public Health, Department of Occupational and Environmental Health, Wuhan 430030, China.
Xiang Zhang — Department of Occupational Health and Environment Health, School of Public Health, Anhui Medical University, Hefei 230032, Anhui, China.
Tong Shen — Department of Occupational Health and Environment Health, School of Public Health, Anhui Medical University, Hefei 230032, Anhui, China.

作者单位

Department of Occupational Health and Environment Health, School of Public Health, Anhui Medical University, Hefei 230032, Anhui, China.
Huaibei Occupational Disease Prevention and Control Hospital of Huaibei Coal Mining Group, Huaibei 235000, China.
Huazhong University of Science and Technology, Tongji Medical College, School of Public Health, Department of Occupational and Environmental Health, Wuhan 430030, China.

摘要

中文

累积夜班暴露可能扰乱昼夜节律稳态，并对呼吸系统健康产生不利影响。在对9,464名煤矿工人的横断面分析中，我们发现，在控制累积可吸入粉尘暴露后，累积夜班暴露量越大，肺功能越低。孟德尔随机化分析支持轮班工作与肺功能降低之间存在潜在因果关联，并进一步表明，基因预测的较低肺功能与较高的慢性阻塞性肺疾病（COPD）风险相关。在煤矿工人亚组中，PER1表达降低部分解释了累积夜班暴露与一秒用力呼气容积（FEV1）和用力肺活量（FVC）之间的关联。公共转录组和单细胞分析显示，PER1在COPD和肺癌相关数据集中表达降低，并提示其与NF-κB相关炎症信号传导存在关联。这些发现表明，PER1相关的炎症信号传导可能是职业性昼夜节律紊乱与呼吸健康损害之间的候选分子桥梁。

English

Cumulative night-shift exposure may disrupt circadian homeostasis and adversely relate to respiratory health. In a cross-sectional analysis of 9,464 coal miners, we found that greater cumulative night-shift exposure was associated with lower lung function after accounting for cumulative respirable dust exposure. Mendelian randomization analyses supported a potential causal link between shift work and reduced lung function and further indicated that genetically predicted lower lung function was associated with higher chronic obstructive pulmonary disease (COPD) risk. In a coal miner subgroup, lower PER1 expression partly accounted for the associations of cumulative night-shift exposure with forced expiratory volume in one second (FEV1) and forced vital capacity (FVC). Public transcriptomic and single-cell analyses showed lower PER1 expression in COPD and lung cancer-related datasets and suggested links to NF-κB-related inflammatory signaling. These findings suggest that PER1-related inflammatory signaling may represent a candidate molecular link between occupational circadian disruption and respiratory health impairment.

分类与指标

研究类型: 临床研究
病种: 肺癌
JCR 分区: Q1
影响因子: 4.5
新锐分区: 3区