← 返回 全部文献 探讨染色体外DNA在肺癌中的作用 Examining the role of extrachromosomal DNA in lung cancer.
期刊 Journal of the National Cancer Institute PMID 42554978 原文 PubMed ↗ 发布日期 2026-08-05 作者 Azhar Khandekar — Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. Phuc H Hoang — Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. Jens Luebeck — Department of Computer Science, University of California San Diego, La Jolla, CA, USA. Marcos Díaz-Gay — Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA. Wei Zhao — Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. John P McElderry — Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. Caleb Hartman — Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. Mona Miraftab — Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. Olivia W Lee — Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. Kara M Barnao — Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. Kristine Jones — Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. Amy Hutchinson — Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. Belynda Hicks — Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. Erik N Bergstrom — Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA. Yang Yang — Ben May Department for Cancer Research, The University of Chicago, Chicago, IL, USA. Martin A Nowak — Department of Mathematics, Harvard University, Cambridge, MA, USA. Nathaniel Rothman — Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. Angela C Pesatori — Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy. Dario Consonni — Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. Robert Homer — Department of Pathology, Yale School of Medicine, New Haven, CT, USA. Marina K Baine — Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Lynette M Sholl — Brigham and Women's Hospital, Boston, MA, USA. Philippe Joubert — Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Canada. Charles Leduc — Centre Hospitalier de l'Université de Montréal, Montreal, Canada. William D Travis — Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Soo-Ryum Yang — Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Qing Lan — Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. David C Wedge — Manchester Cancer Research Centre, The University of Manchester, Manchester, UK. Lixing Yang — Ben May Department for Cancer Research, The University of Chicago, Chicago, IL, USA. Stephen J Chanock — Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. Tongwu Zhang — Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. Ludmil B Alexandrov — Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA. Maria Teresa Landi — Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. 作者单位 Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA. Department of Computer Science, University of California San Diego, La Jolla, CA, USA. Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA. Ben May Department for Cancer Research, The University of Chicago, Chicago, IL, USA. Department of Mathematics, Harvard University, Cambridge, MA, USA. Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy. Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. Department of Pathology, Yale School of Medicine, New Haven, CT, USA. Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Brigham and Women's Hospital, Boston, MA, USA. Institut universitaire de cardiologie et de pneumologie de Québec - Université Laval, Canada. Centre Hospitalier de l'Université de Montréal, Montreal, Canada. Manchester Cancer Research Centre, The University of Manchester, Manchester, UK. 摘要 中文 染色体外DNA（ecDNA）在肺癌中的作用，尤其是在从不吸烟者（LCINS）中，仍不清楚。对1200多例全基因组测序肺癌的检查发现18.9%的患者存在ecDNA。MDM2和其他癌基因通过ecDNA的反复扩增可能驱动LCINS的一个亚型。携带ecDNA的肿瘤比携带其他局灶性扩增的肿瘤表现出更差的总生存期。与全基因组倍增的强关联表明，大多数ecDNA反映了未经治疗肺癌中的基因组不稳定性。
English The role of extrachromosomal DNA (ecDNA) in lung cancer, particularly in subjects who never smoked (LCINS), remains unclear. Examination of over 1200 whole-genome-sequenced lung cancers identified ecDNA in 18.9% of patients. Recurrent amplification of MDM2 and other oncogenes via ecDNA possibly drives a LCINS subset. Tumors harboring ecDNA showed worse overall survival than tumors harboring other focal amplifications. A strong association with whole-genome doubling suggests most ecDNA reflects genomic instability in treatment-naïve lung cancer.
分类与指标 研究类型 临床研究 病种 肺癌 JCR 分区 Q1 影响因子 7.7 新锐分区 1区 