雪茄、小雪茄和烟斗吸烟对肺癌风险和筛查资格的影响

The effect of cigar, cigarillo and pipe smoking on lung cancer risk and screening eligibility.

期刊: British Journal of Cancer
PMID: 42567897
原文: PubMed ↗
发布日期: 2026-08-08

作者

Simran Vaja — Cancer Research UK and UCL Cancer Trials Centre, University College London, London, UK.
Jennifer L Dickson — West Suffolk Hospital Foundation Trust, Bury St Edmunds, UK.
Carolyn Horst — King's College London and Guy's & St Thomas' NHS Foundation Trust, London, UK.
Monica L Mullin — Lungs For Living, UCL Respiratory, Department of Medicine, University College London, London, UK.
Amyn Bhamani — Lungs For Living, UCL Respiratory, Department of Medicine, University College London, London, UK.
Andrew Creamer — Lungs For Living, UCL Respiratory, Department of Medicine, University College London, London, UK.
Helen Hall — Epsom and St Helier Hospitals NHS Trust, Epsom, UK.
Chuen R Khaw — Lungs For Living, UCL Respiratory, Department of Medicine, University College London, London, UK.
Ruth Prendecki — University College London Hospitals NHS Foundation Trust, London, UK.
Priyam Verghese — Lungs For Living, UCL Respiratory, Department of Medicine, University College London, London, UK.
Sophie Tisi — Mid and South Essex NHS Foundation Trust, Basildon, UK.
John McCabe — Lungs For Living, UCL Respiratory, Department of Medicine, University College London, London, UK.
Esther Arthur-Darwka — Cancer Research UK and UCL Cancer Trials Centre, University College London, London, UK.
Neal Navani — Lungs For Living, UCL Respiratory, Department of Medicine, University College London, London, UK.
Anand Devaraj — National Heart and Lung Institute, Imperial College, London, UK.
Arjun Nair — Lungs For Living, UCL Respiratory, Department of Medicine, University College London, London, UK.
SUMMIT consortium
Sam M Janes — Lungs For Living, UCL Respiratory, Department of Medicine, University College London, London, UK.
Allan Hackshaw — Cancer Research UK and UCL Cancer Trials Centre, University College London, London, UK. a.hackshaw@ucl.ac.uk.

作者单位

Cancer Research UK and UCL Cancer Trials Centre, University College London, London, UK.
West Suffolk Hospital Foundation Trust, Bury St Edmunds, UK.
King's College London and Guy's & St Thomas' NHS Foundation Trust, London, UK.
Lungs For Living, UCL Respiratory, Department of Medicine, University College London, London, UK.
Epsom and St Helier Hospitals NHS Trust, Epsom, UK.
University College London Hospitals NHS Foundation Trust, London, UK.
Mid and South Essex NHS Foundation Trust, Basildon, UK.
National Heart and Lung Institute, Imperial College, London, UK.
Cancer Research UK and UCL Cancer Trials Centre, University College London, London, UK. a.hackshaw@ucl.ac.uk.

摘要

中文

如果吸烟者患肺癌的风险足够高，则有资格接受低剂量 CT（LDCT）肺癌筛查。例如，在英格兰，如果使用两种经过验证的模型（PLCOm2012 和 Liverpool Lung Project）中的任何一种估计的风险超过某个阈值，则人们符合资格。风险通常仅使用香烟消费量（持续时间和每日数量）来估计，但许多吸烟者也使用其他致癌烟草制品。SUMMIT 是一项关于 LDCT 筛查服务的前瞻性队列研究。我们评估了雪茄、烟斗和小雪茄对肺癌风险的影响。在 13,000 名当前/既往吸烟者中，511 人（每 25 人中 1 人）也经常使用雪茄、烟斗或小雪茄。目前同时吸食两种类型烟草制品的人群的 5 年累积肺癌发病率为 8.85%，而仅吸香烟的当前吸烟者为 5.74%。在这 511 名参与者中，忽略其他烟草制品时风险低于筛查资格阈值、但纳入这些制品后风险超过阈值的百分比，使用 LLPv2 为 0.6%，使用 PLCOm2012 为 8.2%。在确定筛查资格时，应考虑所有烟草消费，以避免遗漏那些可从 LDCT 获益的人群。Clinicaltrials.gov 编号：NCT03934866。

English

Smokers are eligible for lung cancer screening using low dose CT (LDCT) if they have a sufficiently high risk of lung cancer. In England, for example, people are eligible if their estimated risk using either of two validated models (PLCOm2012 and Liverpool Lung Project) exceeds a certain threshold. Risk is often estimated using only cigarette consumption (duration and number per day), yet many smokers also use other cancer-causing tobacco products. SUMMIT is a prospective cohort study of a LDCT screening service. We evaluated the impact of cigars, pipes, and cigarillos on lung cancer risk. Among 13,000 participants who were current/former cigarette smokers, 511 (1 in 25) were also regular users of cigars, pipes, or cigarillos. The 5-year cumulative lung cancer incidence in people who currently smoked both types of tobacco products was 8.85%, versus 5.74% for cigarette only current smokers. Among these 511 participants, the percentage whose risk was below the screening eligibility threshold ignoring other tobacco products which then exceeded the threshold including these products was 0.6% using LLPv2, and 8.2% using PLCOm2012. All tobacco consumption should be considered when determining screening eligibility to avoid missing those who can benefit from LDCT. Clinicaltrials.gov no: NCT03934866.

分类与指标

研究类型: 临床研究
病种: 肺癌
JCR 分区: Q1
影响因子: 7.8
新锐分区: 1区