中国人群水果和蔬菜摄入与肺癌、结直肠癌、胃癌及总体癌症风险的关系：一项前瞻性队列研究

Fruit and Vegetable Intake in Relation to the Risks of Lung, Colorectal, Stomach, and Overall Cancers in China: A Prospective Cohort Study.

期刊: International Journal of Cancer
PMID: 42575867
原文: PubMed ↗
发布日期: 2026-08-11

作者

Jun Li — Minhang District Center for Disease Control and Prevention (Minhang District Institute of Health Supervision), Shanghai, China.
Xin Yin — Minhang District Center for Disease Control and Prevention (Minhang District Institute of Health Supervision), Shanghai, China.
Genming Zhao — School of Public Health, Fudan University, Shanghai, China.
Xing Liu — School of Public Health, Fudan University, Shanghai, China.
Minqi Wei — Minhang District Center for Disease Control and Prevention (Minhang District Institute of Health Supervision), Shanghai, China.
Jiayue Chen — Minhang District Center for Disease Control and Prevention (Minhang District Institute of Health Supervision), Shanghai, China.
Yonggen Jiang — Songjiang District Center for Disease Control and Prevention (Songjiang District Institute of Health Supervision), Shanghai, China.
Qian Peng — Jiading District Center for Disease Control and Prevention (Jiading District Institute of Health Supervision), Shanghai, China.
Jianhua Shi — Xuhui District Center for Disease Control and Prevention (Xuhui District Institute of Health Supervision), Shanghai, China.
Weixi Li — Minhang District Center for Disease Control and Prevention (Minhang District Institute of Health Supervision), Shanghai, China.
Na Wang — School of Public Health, Fudan University, Shanghai, China.

作者单位

Minhang District Center for Disease Control and Prevention (Minhang District Institute of Health Supervision), Shanghai, China.
School of Public Health, Fudan University, Shanghai, China.
Songjiang District Center for Disease Control and Prevention (Songjiang District Institute of Health Supervision), Shanghai, China.
Jiading District Center for Disease Control and Prevention (Jiading District Institute of Health Supervision), Shanghai, China.
Xuhui District Center for Disease Control and Prevention (Xuhui District Institute of Health Supervision), Shanghai, China.

摘要

中文

尽管既往队列研究已探讨了蔬菜和水果摄入与癌症风险的关系，但结果仍不一致。利用上海郊区成人队列与生物样本库（2016-2019年）中50,987名参与者的数据，通过与癌症登记处的关联（截至2024年6月30日），我们研究了蔬菜和水果摄入与癌症发病风险的关系。总蔬菜和水果摄入量最高四分位数的参与者总体癌症风险较低（HR：0.81，95%CI：0.72-0.90），蔬菜和水果分别分析时也观察到类似的负相关。较高摄入量还与肺癌和胃癌风险降低相关，而结直肠癌未见关联。在连续分析中，总蔬菜和水果摄入量每增加1个标准差，总体癌症风险降低（HR：0.92，95%CI：0.88-0.97），结果与四分位数分析基本一致。亚组分析中，这些负相关在生活方式和健康状况良好的参与者中观察到。RCS分析发现水果摄入量与总体及肺癌风险呈非线性关联，过量摄入时保护作用减弱。

English

Although previous cohort studies have examined the association between vegetable and fruit intake and cancer risk, the findings remain inconsistent. Using data from 50,987 participants in the Shanghai Suburban Adult Cohort and Biobank (2016 to 2019), we investigated the relationship between vegetable and fruit intake and the incidence of cancers through linkage with the cancer registry up to June 30, 2024. Participants in the highest quartile of total vegetable and fruit intake had a lower risk of overall cancer (HR: 0.81, 95% CI: 0.72-0.90), with similar inverse associations observed for vegetables and fruits separately. Higher intake was also associated with lower risks of lung and stomach cancers, whereas no associations were observed for colorectal cancer. In continuous analyses, each SD increase in total vegetable and fruit intake was associated with a lower risk of overall cancer (HR: 0.92, 95% CI: 0.88-0.97), and the findings were generally consistent with those from quartile-based analyses. In subgroup analyses, these inverse associations were observed among participants with favorable lifestyles and health conditions. RCS analyses identified nonlinear associations between fruit intake and the risks of overall and lung cancer, with the protective associations becoming less pronounced at excessive intake levels.

分类与指标

研究类型: 临床研究
病种: 肺癌
JCR 分区: Q2
影响因子: 4.9
新锐分区: 2区