在癌症预防研究中连接空气污染与肺癌的血浆代谢组学特征
Blood metabolomic signatures linking air pollution to lung cancer in the Cancer Prevention Studies.
作者
作者单位
- Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA.
- Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA. ying.wang@cancer.org.
- Department of Population Science, American Cancer Society, Atlanta, GA, USA.
- Department of Radiation Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA.
- Department of Economics, Brigham Young University, Provo, UT, USA.
- Department of Environmental Health Sciences, Fielding School of Public Health, University of California Los Angeles, Los Angeles, CA, USA.
- Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.
- Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA. donghai.liang@emory.edu.
摘要
中文
空气污染是肺癌的主要环境原因，但其潜在生物学通路仍知之甚少。识别捕获早期分子反应的循环生物标志物可能阐明空气污染物如何导致癌变，并帮助识别高风险个体。我们在两个癌症预防研究队列中进行了一项前瞻性巢式病例对照研究，对1357名参与者的诊断前血浆样本进行了超过1100种代谢物的分析。在抽血时估计了六种主要空气污染物的住宅浓度。我们在此显示，八种循环代谢物与空气污染暴露和后续肺癌风险均相关。包括γ-谷氨酰谷氨酰胺、苯乙酰谷氨酸、N-（2-呋喃酰基）甘氨酸和4-乙烯基愈创木酚葡萄糖醛酸在内的四种代谢物显著介导了颗粒物和臭氧的关联（调整后q值<0.2）。这些发现表明，空气污染可能部分通过涉及炎症和氧化过程的代谢通路促进肺癌，为潜在机制和预防靶点提供了关键见解。
English
Air pollution is a leading environmental cause of lung cancer, yet the underlying biological pathways remain poorly understood. Identifying circulating biomarkers that capture early molecular responses may clarify how air pollutants contribute to carcinogenesis and help identify individuals at elevated risk. We conduct a prospective nested case-control study within two Cancer Prevention Study cohorts, profiling more than 1100 metabolites in pre-diagnostic plasma samples from 1357 participants. Residential concentrations of six major air pollutants are estimated at the time of blood draw. Here we show that eight circulating metabolites are associated with both air pollution exposure and subsequent lung cancer risk. Four metabolites, including γ-glutamylglutamine, phenylacetylglutamate, N-(2-furoyl)glycine, and 4-vinylguaiacol glucuronide, significantly mediate associations for particulate matter and ozone (adjusted q-value < 0.2). These findings suggest that air pollution may promote lung cancer partly through metabolic pathways related to inflammatory and oxidative processes, providing key insights into potential mechanisms and targets for prevention.
分类与指标
- 研究类型
- 临床研究
- 病种
- 肺癌
- JCR 分区
- Q1
- 影响因子
- 18.1
- 新锐分区
- 1区