糖尿病作为小细胞肺癌患者不良预后的独立危险因素
Diabetes Mellitus as an Independent Risk Factor for Unfavorable Prognosis in Patients With Small Cell Lung Cancer.
作者
作者单位
- Beijing Chao-Yang Hospital Department of Oncology, Capital Medical University, Beijing, China.
摘要
中文
2型糖尿病（DM）与癌症发生有关，并与癌症患者生存率低相关。然而，DM对小细胞肺癌（SCLC）结局的影响仍不清楚。本研究调查了DM与广泛期小细胞肺癌（ES-SCLC）患者临床结局和长期预后的关系。这项回顾性队列研究使用了接受免疫检查点抑制剂（ICIs）和化疗治疗的ES-SCLC患者的医疗记录。回顾性分析了人口统计学和临床特征。使用Cox比例风险回归进行单变量和多变量分析，以评估临床特征对生存的影响。比较了有或无DM患者的无进展生存期（PFS）和总生存期（OS）。在91名ES-SCLC患者中，32名（35.2%）在ES-SCLC之前被诊断为DM。尽管接受了相当的化学免疫治疗，DM患者的中位PFS（6个月 vs. 15个月，p=0.026）和中位OS（12个月 vs. 22个月，p=0.013）显著短于无糖尿病患者。多变量Cox回归分析显示，DM是较短mOS的独立危险因素（HR 2.05，95% CI 1.02-4.13，p=0.044）。与无糖尿病患者相比，合并糖尿病的ES-SCLC患者的OS和PFS显著缩短。DM是ES-SCLC的独立不良预后危险因素。
English
Type 2 diabetes mellitus (DM) is implicated in cancer development and associated with poor survival in patients with cancer. However, the impact of DM on the outcome of small cell lung cancer (SCLC) remains unknown. This study investigated the correlation between DM and clinical outcomes and long-term prognosis of patients with extensive-stage small cell lung cancer (ES-SCLC). This retrospective cohort study was conducted using the medical records of patients with ES-SCLC treated with immune checkpoint inhibitors (ICIs) and chemotherapy. The demographic and clinical characteristics were retrospectively analyzed. Univariate and multivariate analyses were performed using Cox proportional hazards regression to evaluate the impact of the clinical characteristics on survival. Progression-free survival (PFS) and overall survival (OS) were compared between patients with or without DM. Of the 91 patients with ES-SCLC, 32 were diagnosed with DM before ES-SCLC (35.2%). Patients with DM had significantly shorter median PFS (6 vs. 15 months, p = 0.026) and median OS (12 vs. 22 months, p = 0.013) than those without diabetes, despite receiving comparable chemoimmunotherapy. Multivariate cox regression analysis showed that DM was an independent risk factor for shorter mOS (HR 2.05, 95% CI 1.02-4.13, p = 0.044). Patients with ES-SCLC and comorbid diabetes exhibited significantly shorter OS and PFS compared with those without diabetes. DM serves as an independent adverse prognostic risk factor for ES-SCLC.
分类与指标
- 研究类型
- 临床研究
- 病种
- 肺癌
- JCR 分区
- Q2
- 影响因子
- 2.6
- 新锐分区
- 4区