质子束放化疗后食管鳞状细胞癌的挽救性手术：病例系列研究

Salvage Surgery After Proton Beam-Based Chemoradiotherapy for Esophageal Squamous Cell Carcinoma: A Case Series Study.

期刊: Annals of Surgical Oncology
PMID: 42603834
原文: PubMed ↗
发布日期: 2026-08-16

作者

Hirohito Kakinuma — Department of Minimally Invasive Surgical and Medical Oncology, Fukushima Medical University, Fukushima, Japan. h.kakinuma.0922@gmail.com.
Michitaka Honda — Department of Minimally Invasive Surgical and Medical Oncology, Fukushima Medical University, Fukushima, Japan.
Soshi Hori — Department of Minimally Invasive Surgical and Medical Oncology, Fukushima Medical University, Fukushima, Japan.
Ryuya Yamamoto — Department of Minimally Invasive Surgical and Medical Oncology, Fukushima Medical University, Fukushima, Japan.
Kazuki Nishino — Department of Minimally Invasive Surgical and Medical Oncology, Fukushima Medical University, Fukushima, Japan.
Yoshiaki Takagawa — Department of Minimally Invasive Surgical and Medical Oncology, Fukushima Medical University, Fukushima, Japan.
Nobuyasu Suzuki — Department of Surgery, Southern Tohoku Research Institute for Neuroscience Southern Tohoku General Hospital, Fukushima, Japan.
Yoshinao Takano — Department of Surgery, Southern Tohoku Research Institute for Neuroscience Southern Tohoku General Hospital, Fukushima, Japan.

作者单位

Department of Minimally Invasive Surgical and Medical Oncology, Fukushima Medical University, Fukushima, Japan. h.kakinuma.0922@gmail.com.
Department of Minimally Invasive Surgical and Medical Oncology, Fukushima Medical University, Fukushima, Japan.
Department of Surgery, Southern Tohoku Research Institute for Neuroscience Southern Tohoku General Hospital, Fukushima, Japan.

摘要

中文

尽管基于光子的放化疗后食管鳞状细胞癌（ESCC）的挽救性手术风险很高，但基于质子束的放化疗（PBC）后挽救性手术的安全性仍不清楚。本研究旨在评估PBC后挽救性手术的短期和长期结果。这项单臂回顾性病例系列纳入了2009年6月至2020年2月期间在PBC后因残留或复发ESCC接受根治性挽救性手术的患者。挽救性手术包括食管切除术伴淋巴结清扫或复发淋巴结切除。主要结局是主要并发症（Clavien-Dindo分级≥III）。研究共入组19例患者，中位年龄64岁。19例患者中，12例行食管切除术，7例行淋巴结切除。9例（47.3%）发生主要并发症。无手术死亡。中位总生存期为16.2个月。1年、3年和5年总生存率分别为68.0%、43.1%和35.9%。PBC后ESCC的挽救性手术仍是高风险手术，其可行性应逐例仔细评估。

English

Although salvage surgery after photon-based chemoradiotherapy for esophageal squamous cell carcinoma (ESCC) is high risk, the safety of salvage surgery after proton beam-based chemoradiotherapy (PBC) remains unclear. This study aimed to evaluate the short- and long-term outcomes of salvage surgery after PBC. This single-arm retrospective case series included patients who underwent curative-intent salvage surgery for residual or recurrent ESCC after PBC between June 2009 and February 2020. Salvage surgery included esophagectomy with lymph node dissection or resection of recurrent lymph nodes. The primary outcome was major morbidity (Clavien-Dindo grade ≥III). The study enrolled 19 patients with a median age was 64 years. Of the 19 patients, 12 underwent esophagectomy, and 7 underwent lymph node resection. Major morbidity occurred for 9 patients (47.3%). No operative mortality occurred. The median overall survival was 16.2 months. The 1-, 3-, and 5-year overall survival rates were 68.0%, 43.1%, and 35.9%, respectively. Salvage surgery after PBC for ESCC remains a high-risk procedure, and its feasibility should be carefully assessed on a case-by-case basis.

分类与指标

研究类型: 临床研究
病种: 食管癌
JCR 分区: Q1
影响因子: 3.8
新锐分区: 2区