肺癌放疗患者恒定负荷循环耐力试验的有效性与可行性
Validity and Feasibility of the Constant-Load Cycle Endurance Test in Lung Cancer Patients Undergoing Radiation Therapy.
作者
作者单位
- Rehabilitation Medicine Team, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
- Rehabilitation Research Center, Biomedical Engineering Research Center, Asan Medical Center, Seoul, Republic of Korea.
- Department of Pulmonology and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
- Department of Rehabilitation Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
摘要
中文
本研究评估了在放疗期间肺癌患者中，以最大功率75%进行的恒定负荷循环耐力试验（CET）的有效性，并检验了其在肺康复（PR）中的可行性、反应性和临床适用性。33名患者在放疗期间参加了为期4周的PR计划。将CET时间与6分钟步行试验（6MWT）进行比较以评估同时效度。根据6MWT距离（≥450 m为活跃；<450 m为不活跃）对患者进行分层。在基线和PR后测量CET、6MWT、膝伸肌力量和握力。监测不良事件。CET时间与6MWT距离呈中度相关（r=0.57，p<0.001）。在活跃亚组中相关性更强（r=0.61，p<0.001），但在不活跃亚组中不显著（r=0.09，p=0.63）。PR后，CET、膝伸肌（左）力量（p<0.05）显著改善。亚组分析表明，不活跃患者主要在6MWT上改善，而活跃患者在CET上获益更大。测试或PR期间未发生不良事件。CET与6MWT具有中等效度，并对PR有反应，尤其是在功能能力较高的患者中。CET似乎可行、安全，并可作为步行试验的补充，可能捕获因天花板效应而被掩盖的改善。需要更大规模的研究来确认其作为肺癌PR标准结局指标的作用。
English
This study evaluated the validity of the constant-load cycle endurance test (CET), performed at 75% of maximal power output, in patients with lung cancer undergoing radiation therapy. Its feasibility, responsiveness to pulmonary rehabilitation (PR), and clinical applicability were also examined. Thirty-three patients participated in a 4-week PR program during radiation therapy. CET time was compared with the 6-min walk test (6MWT) to assess concurrent validity. Patients were stratified by 6MWT distance (≥ 450 m = active; < 450 m = inactive). CET, 6MWT, knee extensor strength, and handgrip strength were measured at baseline and post-PR. Adverse events were monitored. CET time showed a moderate correlation with 6MWT distance (r = 0.57, p < 0.001). The correlation was stronger in the active subgroup (r = 0.61, p < 0.001) but not significant in the inactive subgroup (r = 0.09, p = 0.63). After PR, significant improvements were observed in CET, knee extensor (left) strength (p < 0.05). Subgroup analysis indicated that inactive patients primarily improved in 6MWT, whereas active patients showed greater gains in CET. No adverse events occurred during testing or PR. CET demonstrated moderate validity with the 6MWT and was responsive to PR, particularly in patients with higher functional capacity. CET appears feasible, safe, and complementary to walk tests, potentially capturing improvements masked by ceiling effects. Larger studies are needed to confirm its role as a standard outcome measure in PR for lung cancer.
分类与指标
- 研究类型
- 临床研究
- 病种
- 肺癌
- JCR 分区
- Q2
- 影响因子
- 2.6
- 新锐分区
- 4区