肿瘤内微生物群在结直肠癌和肺癌生长中的作用：从病因到治疗的全面见解
Intratumoral microbiota in the growth of CRC and lung cancer: Comprehensive insights from etiology to therapy.
作者
作者单位
- The Second Hospital Affiliated to Dalian Medical University, Dalian Medical University, Dalian, China.
- Advanced Institute for Medical Sciences, Dalian Medical University, Dalian, China.
摘要
中文
肿瘤微环境（TME）含有多种肿瘤内微生物群（ITM），其调控癌症的发生、进展和治疗反应。本综述比较了结直肠癌和肺癌（两种通过肠-肺轴相互关联、解剖位置不同的恶性肿瘤）的ITM特征，并总结了从培养、测序到空间和单细胞技术的微生物检测策略。口腔致病菌如Fusobacterium nucleatum、Streptococcus和Veillonella在这两种癌症中均富集，通过慢性炎症、免疫逃逸、基因毒性损伤、代谢重编程促进肿瘤发生，并通过静脉引流和全身播散促进结直肠癌肺转移。粪便、唾液、血液和肿瘤组织中的微生物特征为检测、预后及免疫治疗耐药预测提供了非侵入性工具，而抗生素、粪便微生物群移植和工程化活体生物治疗剂则提供了重塑TME的策略。本综述将肠-肺轴定位为转移的系统性驱动因素，并描绘了迈向基于微生物组的精准诊断和治疗的道路。
English
The tumor microenvironment (TME) contains a diverse intratumoral microbiota (ITM) governing cancer onset, progression, and therapeutic response. This review compares ITM profiles of colorectal and lung cancer, two anatomically distinct malignancies linked via the gut-lung axis, and summarizes microbial detection strategies ranging from cultivation and sequencing to spatial and single-cell technologies. Oral pathobionts such as Fusobacterium nucleatum, Streptococcus, and Veillonella accumulate in both cancers, promoting tumorigenesis through chronic inflammation, immune evasion, genotoxic insults, metabolic reprogramming, and facilitating colorectal cancer lung metastasis via venous drainage and systemic dissemination. Microbial signatures in stool, saliva, blood, and tumor tissue offer non-invasive tools for detection, prognosis, and prediction of immunotherapy resistance, while antibiotics, fecal microbiota transplantation, and engineered live biotherapeutics offer strategies to remodel the TME. This synthesis positions the gut-lung axis as a systemic driver of metastasis and outlines a route toward precision microbiome-based diagnostics and therapeutics.
分类与指标
- 研究类型
- 综述Meta
- 病种
- 肺癌
- JCR 分区
- Q1
- 影响因子
- 4.5
- 新锐分区
- 3区